Building Predictive Human-Relevant Skin Models to Improve Translational Confidence & Accelerate First-in- Human Readiness

• Developing ex vivo, in vitro and chip-based skin models, improving human relevance, to strengthen confidence before clinical translation
• Testing emerging modalities in engineered model systems, capturing delivery, target engagement and tissue response, to reduce uncertainty before dose selection
• Learning from model innovation to benchmark advanced platform approaches, and improve preclinical decision-making across difficult dermatology questions

Speakers:

Karl Koehler

Associate Professor & Head of Neck Surgery & Otolaryngology, Department of Dermatology,

Harvard Medical School