Travis Whitfill
Chief Operating Officer Azitra
Seminars
Thursday 5th November 2026
Restoring Skin Barrier Function in Ichthyosis Vulgaris: Advancing Topical Filaggrin Replacement to Address the Underlying Disease Biology
2:00 pm
- Targeting the root cause of ichthyosis vulgaris by replacing functional filaggrin protein, restoring skin barrier integrity and addressing the consequences of FLG loss-of-function mutations rather than providing symptomatic relief
- Advancing a novel cell-penetrating topical protein therapy enabling stable delivery of functional filaggrin into the epidermis to improve hydration, barrier function and antimicrobial defence
- Exploring translational and clinical development considerations for first-in-class protein replacement therapies in rare genetic skin diseases, establishing a path toward disease-modifying treatment where effective therapeutic options remain limited
