Targeting Durable Repigmentation through Tissue‑Resident Immune Control in Vitiligo
Time: 11:20 am
day: Day One AM
Details:
- Resident memory CD8⁺ T cells persist in vitiligo lesions and drive relapse even after repigmentation with JAK inhibitors
- IFN‑γ signaling via JAK pathways mediates depigmentation yet inhibition does not deplete Trm cells, limiting treatment durability
- Blocking IL‑15 signaling shows promise in mouse models to eliminate Trm and achieve sustained repigmentation beyond temporary response
- Emerging clinical strategies focus on combining pathway-targeted agents with durable endpoints and relapse-prevention frameworks
